- Drug Discovery
- Integrated Drug Discovery
- Bioscience
- Ion Channel Screening
- Cell Line Generation
- Assay Development
- Screening
- Cell Based Assays
- Biochemical Assays
- Biophysical Characterisation
- Surface Plasmon Resonance (SPR)
- Fluorescent Thermal Shift Assays (FTSA)
- Nuclear Magnetic Resonance (NMR)
- Flow Induced Dispersion Analysis (FIDA)
- Protein Mass Spectrometry
- X-Ray Crystallography (XRC)
- Isothermal Titration Calorimetry (ITC)
- Microscale Thermophoresis (MST)
- Dynamic Light Scattering (DLS)
- Biomarker Discovery
- Primary Tissues
- Protein Science and Structural Biology
- Chemistry
- Computer Aided Drug Design (CADD)
- DMPK
- In Vivo Pharmacology
- Form and Formulation
Biomarker Discovery
A high quality, sensitive biomarker can provide vital information to project teams throughout the Biomarker Discovery and development pipeline, information which can be used to instruct project progression strategies into the clinic.
Biomarker Discovery Identification
Sygnature’s collaborative and flexible approach to biomarker identification and validation ensures the development of an appropriate and robust biomarker that is fit for purpose.
We have developed a wealth of expertise in the identification and validation of pharmacodynamic (PD) biomarker such as genes, phosphoproteins and cytokines.
Our scientists offer biomarker discovery, identification and assay development expertise across a range of therapeutic areas.
- Drug Discovery
- Integrated Drug Discovery
- Bioscience
- Ion Channel Screening
- Cell Line Generation
- Assay Development
- Screening
- Cell Based Assays
- Biochemical Assays
- Biophysical Characterisation
- Surface Plasmon Resonance (SPR)
- Fluorescent Thermal Shift Assays (FTSA)
- Nuclear Magnetic Resonance (NMR)
- Flow Induced Dispersion Analysis (FIDA)
- Protein Mass Spectrometry
- X-Ray Crystallography (XRC)
- Isothermal Titration Calorimetry (ITC)
- Microscale Thermophoresis (MST)
- Dynamic Light Scattering (DLS)
- Biomarker Discovery
- Primary Tissues
- Protein Science and Structural Biology
- Chemistry
- Computer Aided Drug Design (CADD)
- DMPK
- In Vivo Pharmacology
- Form and Formulation