Iterative Screening

Sygnature’s experience together with our open and transparent communication, enhanced by the co-location of our scientific teams, ensures efficient, cost-effective and optimised Design-Make-Test-Analyse cycles to expedite the progression of your project through the discovery pipeline.

Our state of the art automated liquid-handling capabilities enables rapid and robust turnaround of routine screening data, with either ‘spot’ tests at a single concentration or full concentration-response curves being generated for each test compound. Together with Sygnature’s comprehensive Informatics System, our automation platform and the experience of the scientific teams, facilitates accelerated design-make-test-analyse (DMTA) cycles, to rapidly identify Structure-Activity Relationships (SAR) to enable efficient compound optimisation and clinical candidate nomination.

Result: Clinical candidate nomination with the desired property profile for the target of interest.