Medicinal Chemistry

Navigating the drug discovery pipeline comes with many challenges. Sygnature Discovery’s integrated drug discovery approach supports your projects with hit identification, lead optimisation and preclinical testing as a strategic partner.

Working collaboratively, our highly innovative medicinal chemistry teams will add value to your project alongside colleagues from our bioscience, computational chemistry and DMPK departments as well as your own scientists, ensuring the best approach for your project.

Here at Sygnature, we pride ourselves on our ability to work flexibly, to meet the diverse demands of today’s modern medicinal chemistry programs. Your program will be tailored to your specific requirements using the most efficient screening cascade.

Our wide-ranging expertise and ability to conduct a hypothesis-driven approach with rapid data generation is why our customers continue to seek out our medicinal chemistry department.

Sygnature Discovery can provide:

• Library synthesis and scaffold design for rapid access to a large number of compounds for SAR evaluation.
• Analysis of data, identifying trends and providing support for informed selection of the next synthetic targets via Dotmatics database and Vortex software.
• Early assessment and monitoring of ADMET properties to guide design of high-quality candidates.
• Broad experience on a variety of prodrug technology platforms, including time-and pH-release linker strategies, GI-targeted delivery and optimisation of stability and solubility of the parent compound provides avenues of exploration.