Protein Science & Structural Biology

With over 60 protein scientists at Sygnature Discovery worldwide, we take great pride in providing high quality, fully characterised proteins for a wide range of applications: such as enzymatic assays, in vivo studies, diagnostic kits, biotherapeutics,  crystallography, Cryo-EM and many others.

Why choose us? Challenging targets

Where we come into our own, is that we welcome challenging protein targets where we can truly leverage our extensive knowledge and expertise.

We’ve successfully tackled:

• Unprecedented membrane proteins
• Intrinsically disordered proteins
• Refolding from inclusion bodies
• Large protein complexes
• Labelled proteins for NMR studies
• RNA structures by crystallography

Across our capabilities

Protein Expression & Purification 

• Vast diversity of proteins produced. Designed for end use.
• HEK, CHO, Insect, E.coli from mL to 25L scale.
• Significant expertise in membrane protein production.
• Very experienced in producing antibodies and Ab fragments.

Structure Determination

• Proteins, Complexes, Antibody/Antigen Interaction, RNA.
• X-Ray Crystallography, Cryo-EM and NMR.

Protein Characterisation & Quality Control

• Mass spectrometry – intact protein, peptide mapping and native.
• NMR, FIDA, ITC, SEC-MALS and FSEC.
• SPR, DLS, MST, FTSA and CETSA.

Compound Screening

• Fragment Based Drug Discovery supported by Crystallography or SPR & MST.
• NMR in solution – Ligand observed and Protein observed.
• Covalent compound binding by mass spectrometry.

Working with us – Communication is key

• We operate various contract models to suit your particular project needs
  • Standalone fee for service
  • Full time equivalent either standalone or as part of a fully integrated project involving other departments from Sygnature Discovery.
• For any project we spend time and work hard to understand your particular needs and provide our expert opinion with suggestions on how to prosecute the project.
• A member of the team is assigned as project lead to be your point of contact with respect to timings, logistics, discussion of data and project deliverables.