Protein Mass Spectrometry

Dynamic Light Scattering (DLS)

Our biophysicists can assess the aggregation behaviour of your compounds, targets and complexes within solution using DLS techniques. This can assist you in the characterisation of lead compounds and in the development of drug delivery systems or biologic therapeutics.

Fluorescent Thermal Shift Assays (FTSA)

Obtain high-quality insights into the thermal unfolding, stability, and ligand effects of your protein target with our FTSA (Differential Scanning Fluorimetry or DSF). Discover valuable information to refine the binding mechanism of action for your drug target.

Isothermal Titration Calorimetry (ITC)

Gain valuable insights into the binding mechanism of novel compounds during lead identification through our comprehensive thermodynamic and kinetic profiling services, utilising ITC analysis to determine crucial parameters for your drug candidate research.

Surface Plasmon Resonance (SPR)

Our biophysicists are proficient using state-of-the-art equipment to carry out label-free SPR assays, which measure compound, fragment or larger species (e.g., protein-protein) binding in real-time to generate accurate kinetic and binding mechanism information about a wide range of drug targets.

Microscale Thermophoresis (MST)

Leveraging a robust homogeneous assay solution-based technology, Sygnature Discovery analyses precise thermal gradient effects on molecular properties to assess ligand binding interactions. Our skilled biophysicists provide valuable insights that complement SPR findings.

X-Ray Crystallography (XRC)

Enhance your discovery program with X-ray crystallography (XRC) - precise mapping of interaction sites in lead protein molecules.